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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs
For instance, dietary polyphenols such as caffeic acid and quercetin react slowly, which may lead to underestimation when using short reaction times (Pulido et al