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In a Phase I clinical trial in patients with refractory malignant tumors (n = 15), the drug only induced self-limiting Grade 1 hypercalcemia with mild and reversible hypercalcemia, with no Grade 3 or higher toxicities, demonstrating clinically acceptable safety (Beer et al., 2001)

Niculescu A-G, Grumezescu AM

Herskowitz: Before any of the EBOO treatments, yes

doi: 10.1016/j.biopha.2016.04.022 67 TortorellaSMRoyceSGLicciardiPVKaragiannisTC

Gallagher PM, Meleady R, Shields DC, Tan KS, McMaster D, Rozen R, Evans A, Graham IM, Whitehead AS

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