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Structured weight management programmes delivered through primary care or specialist services provide dietary counselling, physical activity support, and behavioural modification strategies without pharmacological side effects

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Author contributions UK: Methodology, Data curation, Investigation, Software, Conceptualization, Writing review & editing, Visualization, Resources, Writing original draft, Formal analysis

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To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig