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As encouraged by Llins et al (76), Despite significant investment in processes to find all the possible polymorphs of active pharmaceutical ingredients (APIs), new polymorphs can suddenly appear without warning

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In a HA- hydrogel containing resveratrol-loaded (10 mg) chitosan (CS) nanoparticles, release of resveratrol was observed, and it counteracted oxidative damage that was induced by ROS generation in a TNF-/IFN--treated (AD-like) human keratinocytes, without induction of cell death [191]

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