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In the epidermis, melanocytes produce melanin, which gives our skin its color and protects us from sunburn [212]

It is recognized for potential therapeutic effects on gastrointestinal health and tissue repair , supporting the healing of muscles , tendons , and the gut lining

Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

A research guide to mechanism, the documented decline with ageing, and laboratory applications

In addition, the mitochondrial membrane potential (m), which is the polarity of mitochondria, is generated by the activity of mitochondria

doi: 10.1038/s41467-023-36708-5 30 WangHLinFXuZYuSLiGLiaoSet al