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This is the first study that reveals the crosstalk between aldehyde metabolism and ferroptosis pathways using an in vivo model

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PMID: 40570559 Phytomedicine Gut microbiome and metabolomic profiles reveal the antiatherosclerotic effect of indole-3-carbinol in high-choline-fed ApoE-/- mice

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A clinical proof-of-concept trial used 0.03 mg/kg twice daily for short durations and found the drug to be generally well tolerated, though efficacy endpoints were mixed depending on the indication

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