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The HO-1 increases the expression of super oxide dismutase which can protect against uncoupling of NOS (47-49)

These results suggest that the decline in glutathione in neurons is more critical for the brain atrophy than that in astrocytes

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doi: 10.2337/diacare.24.4.775 24 MatthewsDRHoskerJPRudenskiASNaylorBATreacherDFTurnerRC

Bile Acid TUDCA Improves Insulin Clearance by Increasing the Expression of Insulin-Degrading Enzyme in the Liver of Obese Mice. Vettorazzi, Jean Franciesco, Rosane Aparecida Ribeiro, et al