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Secondary osteoporosis: obesity, diabetes, long-term sedentary, hormone drugs, excessive fat reduction, etc., interfere with calcium and phosphorus metabolism, inhibit osteogenesis, promote osteoclasis, and cause bone loss

1 Introduction The unprecedented pace of industrialization and urbanization over recent decades has introduced a vast array of chemical contaminants into our environment, among which environmental endocrine disruptors (EEDs) have emerged as a particularly concerning threat to human reproductive health ( 1.1 Sources and classification of EEDs Environmental endocrine disruptors encompass a remarkably diverse array of chemical compounds that can be systematically categorized into three distinct groups based on their origin, chemical properties, and environmental behavior: Heavy Metals and Metalloids represent one of the most persistent categories of reproductive toxicants