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However, because of their lesser magnitude of glucose lowering, they are prescribed more commonly as an addition to another type of medicine rather than as monotherapy: Metformin: First-line therapy that decreases hepatic glucose output

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The swinging arm allows for efficient substrate channeling and catalytic turnover preventing the release of intermediates

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Therefore, in order to overcome the survival crisis caused by oxidative stress, cancer cells are likely to exhibit metabolic preferences and undergo metabolic reprogramming, including but not limited to GSH metabolic rewiring

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