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Individuals with pre-existing medical conditions, or those who are pregnant or nursing, should consult a doc

HRT provides hormonal support for muscle, but it cannot prevent muscle loss from caloric deficit and disuse

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Not every patient is an appropriate candidate, and a responsible clinician will always screen before recommending treatment

Consequently, a comprehensive and systematic understanding of the specific molecular regulatory mechanisms of mitochondrial quality control using novel technologies and methodologies is a pivotal objective of future research (Figure 4)