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Skin changes associated with weight loss may include increased skin laxity, particularly in areas where substantial fat loss occurs, such as the face, arms, abdomen, and thighs

the National Key R&D Program of China (2022YFC2703105 to HEX, 2019YFA0904200)

Designing future studies may require careful attention to which endpoint is primary, as that will dictate whether a lower, moderate, or higher dose is emphasised