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34 Cellular studies have suggested that ALA may induce nuclear localization of nuclear factor erythroid 2-related factor 2 (NRF2), the most important transcription factor regulating genes that contain the antioxidant response element, thereby modulating peroxisome proliferator-activated receptors-regulated genes

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Experimental work on intestinal anastomosis models and related gastrointestinal injury systems has evaluated endpoints including tissue tensile strength, inflammatory signaling markers, and vascularization within healing intestinal segments

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Yazbeck et al

doi: 10.1111/j.1365-2036.2011.04939.x 212 ZoccoMADal VermeLZCremoniniFPiscagliaACNistaECCandelliMet al