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Abbreviations LAB: Lactic acid bacteria GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species CDM: Chemically defined medium gshA: -glutamylcystiene synthetase gshB: glutathione synthetase gshF/gshAB: glutathione biosynthesis bifunctional fusion gene gor / gshR : glutathione reductase gpo: glutathione peroxidase gst: glutathione S-transferase cydDC: putative cysteine and glutathione importer

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Pathogenic genetic variants in NAD-synthesis enzymes lead to NAD + deficiency 14

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