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In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)

Pharmaceutics 12:311311 Kim JH, Ryu CH, Chon CH, Kim S, Lee S et al (2021) Three months extended-release microspheres prepared by multi-microchannel microfluidics in beagle dog models

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