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The American Migraine Foundation notes that IV magnesium appears most effective in patients with migraine with aura, likely because magnesium helps prevent cortical spreading depression the brain signaling wave thought to underlie visual and sensory aura

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A randomized-controlled trial, also published in The New England Journal of Medicine, found that those taking the higher dose of tirzepatide had a 21.4% reduction in body weight in just over a yeara much higher reduction compared with placebo at 2.5%

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