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This work was supported by Al-Zaytoonah University of Jordan research funds (2019-2020/23/06) and (2022-2023/17/48)

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Notably, these extracts (especially leaf extracts) showed enhanced effects in strengthening intracellular antioxidant defences like catalase, superoxide dismutase, and glutathione to lower lipid peroxidation products and reduce prominent pro-inflammatory markers such as tumor necrosis factor-, interleukin (1L)-, IL-6, monocyte chemoattractant protein-1 and nitric oxide synthase

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The fungal metabolite cyclonerodiol inhibits IL-4/IL-13 induced Stat6-signaling through blocking the association of Stat6 with p38, ERK1/2 and p300