deviation may reduce safety and efficacy
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These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro), which is a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist
"The label on GLP-1 medications say they are to be used 'in combination with a reduced-calorie diet and increased physical activity'," said Geoff Cook, Chief Executive Officer of Noom
It also triggers mucus hypersecretion by inactivating the transcription factor FOXA2 and enhancing the IL-4/IL-13-STAT6 and EGFR-AKT/ERK1/2 signaling pathways, leading to goblet cell metaplasia and increased mucin production
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