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We haven't really had a new tool in our toolbox from a pharmacotherapy perspective to treat addiction in a long time, said Lembke, noting that some addiction specialists are already prescribing GLP-1s off-label, especially when other treatments have failed

once a threshold is reached, the excess is excreted rather than absorbed

These activated Kupffer cells release locally acting cytokines that, like in adipose tissue, exacerbates the pro-inflammatory environment

Common side effects are gastrointestinal nausea, vomiting, and diarrhoea and are most pronounced during dose escalation

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