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In the gastrointestinal tract, current studies have identified that metformin effects glucose uptake and absorption, influences GLP-1 secretion, modulates immune homeostasis, and regulates the gut microbiota, detailed information was drawn in Figure 1

155 The anthracycline antibiotic doxorubicin (DOX) is a widely used anti-tumor drug in solid malignant tumors

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Longitudinal studies (Khavinson et al.) in rodents have demonstrated that Epithalon can increase maximum lifespan by 11-25%

[9] [10] However, older adults with severe heart failure or significant renal impairment require careful assessment, as dehydration from gastrointestinal side effects may exacerbate kidney function decline and increase acute kidney injury risk