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Evidence of mitochondrial dysfunction in autism: biochemical links, genetic-based associations, and non-energy-related mechanisms

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41 As discussed above, mitochondrial dysfunction (mitochondrial bioenergetics, calcium buffering) and mitochondrial quality control systems (mitochondrial dynamics, mitophagy, mitochondrial biogenesis) may be involved in the pathological mechanisms of diabetes-related NDs

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Notably, 50% of measured NADP + in frozen blood originated from NADPH, allowing for extrapolation of NADPH and NADP + levels before freezing, if fresh sample analysis is not feasible