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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

It needs to be reconstituted prior to use

Most people start noticing an improvement in energy levels within 2-3 weeks

Other antihypertensive medications should not be taken at the same time as hydralazine

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It is found naturally in animal products such as meat, oily fish, eggs and dairy products