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Real-world Data and Treatment Guidelines One of the strengths of this study was its use of real-world data, providing valuable insights into the effectiveness of semaglutide outside of controlled clinical trials

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In TRIUMPH-2, which enrolled adults with obesity or overweight and type 2 diabetes, participants receiving the highest 12 mg dose lost an average of 20.8% of their body weight during 80 weeks, compared with 3.2% for placebo

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We shouldnt be surprised that they gain the weight back because, effectively, the semaglutide is influencing energy balance, so what the body takes in and what it takes out, in an artificial way. That doesnt mean the drug isnt helpful: Getting weight off people for a period of time is better than not having the weight off them at all, says Gately