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10.1038/nm.3128

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A multi-hit model for the neutralization of animal viruses

Cytochrome c oxidase subunit 7A1 (COX7A1) exhibits a distinct dual role: It enhances mitochondrial metabolism to sensitize NSCLC cells to cysteine deprivation-induced ferroptosis, while concurrently inhibiting autophagy to block mitochondrial remodeling, two seemingly opposing effects

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Key components include resistance training and daily moderate aerobic exercise, adequate high-quality protein intake (1.21.6 g/kg adjusted body weight/day) distributed evenly across meals, micronutrient supplementation, and periodic reassessment of lean mass via DXA, BIA or functional outcomes (e.g., handgrip strength and gait speed) to optimize fat loss while minimizing sarcopenia risk (Table 2)