The lesions appeared in groups and showed slow extension but were persistent and symmetrical in distribution
Consideraciones importantes: 1
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The presence of risk factors for overdose should not prevent the management of pain in any patient (see WARNINGS
Lipotoxicity and Ectopic Fat Deposition When adipose tissues capacity to safely store excess nutrients is exceeded or functionally impaired, free fatty acids (FFAs) flux increases, resulting in ectopic lipid deposition in non-adipose organs such as the liver, pancreas, and skeletal muscle, thereby exacerbating insulin resistance and -cell stress [19]
They function by inhibiting the formation of autolysosomes and are favored due to their well-defined safety profiles and established dosing regimens [97, 98]
