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Newer glucose-lowering drugs and risk of gout: a network meta-analysis of randomized outcomes trials

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36 The superior antagonist activity of the Gly4( S,S )-ACPC derivative relative to exendin-(9-39) suggests that the N-terminus of the ( S,S )-ACPC-containing peptide engages the TMD in a manner that is energetically favorable but ineffective for GLP-1R activation

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However, natural GLP-1 can easily be degraded by dipeptidyl peptidase 4 (DPP-4) in vivo and lose its activity