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10.1038/nrneph.2012.19 24

(38431210) Relative glutathione depletion may contribute: Glutathione deficiency up-regulates glutamylcysteine synthetase, which increases the level of glutamylcysteine

It was demonstrated that melatonin inhibits the phosphorylation of ERK1/2, which is required for the epithelial-to-mesenchymal transition in gallbladder cancer cells, and therefore could similarly do so in HCC [106]

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This dual action, enhancing inhibitory GABA while reducing excitatory NMDA, creates conditions favorable for transitioning into and maintaining sleep