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Because they handle so much oxygen, mitochondria naturally generate ROS as a byproduct of energy production

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[8] An imbalance in GSH and its use as a marker of oxidative stress is reported in many diseases including cancer, neurodegenerative disorders, cystic fibrosis, HIV,[ 9] diabetes mellitus, 10 anorexia nervosa 11 and autism [12, 13] and in low-birth-weight neonates