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PubMed Jastreboff AM, Aronne LJ, Ahmad NN, et al

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Orforglipron In phase II, randomized, double-blind study, adults with overweight or obesity and without T2DM who took oral orforglipron (12, 24, 36, or 45 mg) daily for 36 weeks experienced a weight reduction of 9.414.7% [105]

There isn't a lot of research on the health effects of periodic use, though other studies show weight regain after stopping GLP-1s is faster compared to other diets that focus on behavior changes

Insulin therapy, delivered via subcutaneous (SC) injections or continuous subcutaneous insulin infusion (CSII) systems, remains indispensable, particularly in individuals with T1DM and those with progressive or inadequately controlled T2DM

My clothes fit better, belly flab is nearly gone, and bloatings vanished