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Additionally, Luo et al

Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

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Paraventricular hypothalamic nucleus MCR 4 receptor expressing neurons are prototypical neurons in the melanocortin induced regulation of satiety and body weight

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