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The proline at position 172 is thought to play a crucial role in positioning Lys171 correctly with respect to the substrate, G6P

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The utility of LNPs has been further expanded by Andrew Tsourkas team, who employed them to deliver protein-based bifunctional degraders (bioPROTACs), thereby overcoming the membrane permeability limitations of small-molecule PROTACs and achieving TPD within subcellular compartments like mitochondria and the nucleus [188]