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HGF is mainly secreted by stromal cells and activates c-MET on neighboring epithelial cells via paracrine signaling

Brain 147 , 444457 (2024)

These symptoms may indicate your dose needs adjustment or that an underlying metabolic condition requires evaluation

high blood pressure, sleep apnoea, type 2 diabetes) In some cases, a BMI of 3034.9 with significant weight-related health risks, if referred by a specialist weight management service For people of South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean heritage, lower BMI thresholds may apply (usually reduced by 2.5 kg/m) Private prescriptions Criteria can be less restrictive: Many providers will consider prescribing from a BMI of 27 if there are weight-related health concerns Some will only require a BMI of 30 or above without additional conditions The prescriber must still assess safety and suitability based on your medical history Important: BMI is only one part of the assessment your prescriber will also consider your health risks, medication history, and readiness for lifestyle changes

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