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For others, the discomfort persists well beyond the expected window, and this is often a sign that the gut microbiome has not been adequately supported during the transition

However, NICE guideline NG28 specifies continuation criteria: treatment should be reviewed after approximately 6 months and only continued if you've achieved both a reduction in HbA1c of at least 11 mmol/mol (1%) and weight loss of at least 3%

Instruct patients to inform healthcare providers of any planned surgeries or procedures (5.9)

This often involves higher target doses compared to diabetes indications, reflecting the need for stronger appetite suppression and metabolic effects

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