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N Engl J Med 377:839848 Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR et al (2019) Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes

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Returning to GLP-1 Therapy Treatment breaks can be temporary

As mentioned above, there is some incidence of a phenomenon referred to as a post-injection flare wherein the injection of fluid into the knee stretches the knee capsule and induces an initial inflammatory pain response that can last for a day or so

Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, et al