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Honest contraindication review: Active or recent malignancy, pregnancy, breastfeeding, uncontrolled diabetes, and severe pituitary disease are real contraindications

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"Therefore, compounded drugs should only be used to meet a patient's needs if they cannot be met by an available FDA-approved drug," the agency concluded

Meta-analyses show an overall relative risk increase of about 1.37-fold, with higher risk at higher doses and longer treatment duration

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Bundled medication purchases therefore face higher regulatory scrutiny