doi: 10.1038/35025220 65 MandriotaSJJussilaLJeltschMCompagniABaetensDPrevoRet al
The selectivity that makes ipamorelin special, not raising cortisol, prolactin, or other hormones, should persist with continued use
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A newer study, published in 2023, showed that acute NR supplementation (900 mg) raised mean cerebral NAD+ concentration from 0.392 mM to 0.458 mMabout 16% higher than baseline [17]
[Ref] Cardiovascular Very common (10% or more): Increased heart rate Common (1% to 10%): Hypotension Uncommon (0.1% to 1%): Orthostatic hypotension Increased heart rate was reported with a mean increase of 1 to 4 beats per minute (bpm) across trials, with maximum changes of 10 to 19 bpm in up to 41% of treated adult patients vs 34% placebo, and 20 bpm or more in up to 26% vs 16% placebo
The company is focusing on looking at its technology to blockbuster drug classes, specifically GLP1 receptor agonists used in diabetes and obesity treatments
