Polyphenols (secondary plant substances, e.g
In HESC cells (Fig
These peripheral and central deficits can include severe gastrointestinal lesions, intracranial (superior sagittal sinus) hypertension, brain swelling and lesions, portal and caval hypertension, aortic hypotension, peripheral and central thrombosis, inferior caval vein and superior mesenteric vein congestion, azygos vein failure, electrocardiogram (ECG) disturbances, and heart, lung, liver, and kidney lesions (Vukojevic et al., 2018
The most common side effects are nausea, vomiting, constipation, and digestive upset, especially at the beginning of therapy
Unlearn works with pharma sponsors, biotech companies, and academic institutions
Small molecule SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate