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Van Der Heijde, David Mason, Robert Landew, Ronald Van Vollenhoven, Bernard Combe, Paul Emery, et al

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Activation of the AR complex can also occur via crosstalk with other signaling pathways, such as those mediated by the non-receptor tyrosine kinases Src and Ack1 139,148,149,150,151

These changes lead to an overall increased permeability of the BBB and imbalance of the CNS microenvironment, as well as the potential introduction of pathogens and neurotoxins into the brain that can contribute to neurodegenerative processes (Funk et al., 2021

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Acknowledgements The authors acknowledge the efforts of Prof Omnia ElRashidy one of the founders of the Pediatric Ketoclinic and Prof Ehab Khairy Emam the Head of the Pediatric Gastroenterology, Hepatology and Clinical Nutrition Unit, at the children`s Hospital, Faculty of Medicine, Ain shams University, for their support