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A high-fat diet has been shown to reduce gram-positive Bifidobacteria levels in the digestive system while increasing the amount of intestinal microbes that hold LPS, both of which contribute to obesity, the primary risk factor for CVD (39)

We also confirmed the role of GLP-1R on microglia in lipopolysaccharide (LPS)-incubated BV-2 cells

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Nonetheless, clinical trials involving both healthy individuals and those with mild cognitive impairment or AD are warranted to investigate whether melatonin can enhance the glymphatic systems efficacy in reducing brain concentrations of A and tau