In diabetic state, hyperglycemia leads to overproduction of free radicals (i.e., mitochondrial , NO and peroxynitrite) mainly derived from glucose oxidation and lipid peroxidation, which cause oxidative damage to biomolecules
We do now have drugs (Dononamab and Lecanemab) which show some benefit and one might consider whether these should be the placebo treatments against which new drugs are tested. Prof Paresh Malhotra , Group Leader at the UK Dementia Research Institute Care Research & Technology Centre and Head of the Division of Neurology at Imperial College London said: "These two linked trials show that, unfortunately, semaglutide appears to have no effect on progression in people with established Alzheimers disease, including people who have evidence of some damage to brain blood vessels
Some competitors charge a non-refundable consultation fee regardless of the outcome
Less common but more serious risks include pancreatitis, gallbladder problems, and low blood sugar when used with other diabetes medications
I think on a on a health economics on a health equity perspective, there needs to be broader availability of Roux-en-y gastric bypass and accessibility to those people on an absolutely equitable basis
It signals your pancreas to release insulin, which carries glucose to your cells rather than leaving it in your bloodstream
