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B12 requires active folate (5-methyltetrahydrofolate) to function properly in the methionine synthase reaction, but folate levels are often low in people with MTHFR variants

doi: 10.1210/jcem.79.5.7525636 164 HwaVTomasini-SprengerCBermejoALRosenfeldRGPlymateSR

"Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis." Clinical Nutrition ESPEN

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Peoples, J

A Mediterranean-style diet rich in healthy fats like olive oil and omega-3 fatty acids from fish has been shown to support metabolic health effectively