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Reduced -adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock

Independent groups working with aging human fibroblasts have reported something genuinely tantalizing: in late-passage cells, the ones that have divided many times and started to look worn, GHK exposure can shift gene-expression patterns partway back toward a younger profile

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Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with T2D (73.1% with prior CV disease): Primary MACE: HR 0.91 (95% CI 0.83-1.00, p=0.06 for superiority) Non-inferiority achieved

While this might sound appealing if youre tired, the trade-offs include anxiety, elevated heart rate, sleep problems, and potential for dependency