That level of reduction, sustained over months, produces the dramatic weight loss seen in clinical trials
Since natural GLP-1 is rapidly deactivated by an enzyme in our blood, by the time GLP-1 is secreted by our gut, makes it through our liver, heart, and lungs, then out into our arteries, only to later reach the veins where the lab tech is pulling out blood, the levels we see are lower than the arterial levels that GLP-1 receptors are exposed to throughout our body, though only by a relatively small amount
Key takeaways Wegovy is administered once weekly on the same day each week through subcutaneous injection into the thigh, abdomen, or upper arm, with sites rotated to prevent skin irritation
However, their long-term liver-related benefits, safety, and sustainability remain unproven, and thus, they are not currently recommended in clinical guidelines
Published February 12, 2021
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