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We thank Drs Brian Sweatman and John Haselden of GlaxoSmithKline, Ware, UK for generous access to high-resolution NMR facilities

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Interestingly, a SLC25A39 -associated human phenome analysis using 4,000 traits in the UK Biobank (n=361,194 subjects) revealed reticulocyte count and hemoglobin concentration as the top significant phenotypes associated with genetically regulated SLC25A39 expression (Extended Data Fig

Acknowledgements The authors acknowledge the efforts of Prof Omnia ElRashidy one of the founders of the Pediatric Ketoclinic and Prof Ehab Khairy Emam the Head of the Pediatric Gastroenterology, Hepatology and Clinical Nutrition Unit, at the children`s Hospital, Faculty of Medicine, Ain shams University, for their support

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