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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
I think we got to get away from using BMI sometimes. So think of the table above as telling you whether the conversation is worth having
Back down the mountain
Some people may lose a few pounds in the first week due to a reduced appetite or smaller portion sizes
The gastric-emptying effect often attenuates over time after dose stabilization
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Logging your food helps you notice which meals keep your cravings quiet, and the recipe builder makes it easy to create lighter, protein-friendly sweet treats that actually fit your day
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