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For LCMS analysis, metabolite extracts were analysed by high-resolution mass spectrometry with an Orbitrap Exploris 240 (Thermo) coupled to a Vanquish Flex liquid chromatography system (Thermo)
Acta Paediatr 2024;113:26822683
[Abstract]2025 Nov 7;11(1):511
Some researchers also use a vial stand to keep the peptide vial upright and stable during preparation
Dose escalation phase (titration) Tirzepatide titration (dose escalation) typically follows this schedule: Month 2: 4-6 mg once weekly Month 3: 6-8 mg once weekly Month 4: If tolerated, increase to 8-10 mg once weekly Month 5: If the dosage needs to be escalated further, increase to 10-12 mg once weekly Month 6 and onward: If the dosage needs to be escalated further, increase to 12-14 mg once weekly The maximum dosage is typically 14 mg once weekly if further glycemic control or weight loss is required
Discussion Our data revealed that analysis of 34 serum metabolites was sufficient to discriminate between controls and schizophrenia patients by OPLS-DA (Fig
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