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However, BPC 157 is a therapeutic agent not approved by the FDA, which cites risk of immunogenicity, peptide-related impurities, and limited safety-related information as reasons for banning BPC-157

15 A similar study on venous ulcers in CVI showed a reduction of the ulcer area by 38.6% with Pycnogenol and by 31.5% in the control group using diosmin/hesperidin (Figure 3)