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Additionally, a long-term extension study established that Vtamas effects were durable and its tolerability profile remained favorable over 48 weeks of follow-up

The mechanism is plausible (direct delivery should theoretically accelerate results), but the evidence base is not comparable to what exists for topical application

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Those with severe kidney or liver dysfunction should proceed with caution, as impaired organ function may slow peptide clearance

The method of embodiment 81, wherein the external beam radiation therapy is three-dimensional conformal radiation therapy (3D-CRT), image guided radiation therapy (IGRT), intensity modulated radiation therapy (IMRT), helical-tomotherapy, photon beam radiation therapy, proton beam radiation therapy, stereotactic radiosurgery, stereotactic body radiation therapy (SBRT), or intraoperative radiation therapy (IORT)