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Peripheral neuropathy Antiretroviral-related peripheral neuropathy The use of certain antiretroviral agents (nucleoside analogs) has been associated with an increased risk of developing peripheral neuropathy in HIV-positive individuals (77, 78)

These results supported the hypothesis that ACTL6A impacts GSH de novo synthesis mainly by regulating GCLC expression

Link: Longo N, et al

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240 Furthermore, the expression of enzymes in the NAD + salvage pathway, including Nmrk1, Nampt, and Nadk, has circadian oscillation patterns in WT and Liver-RE mice that exclusively express BMAL1 in the liver, suggesting the circadian clock might reprogram NAD + salvage synthesis to maintain the fluctuation of NAD +