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Individual outcomes can differ depending on factors like initial weight, dosage, lifestyle, and the bodys response to the medication

Furthermore, the weight loss effect of GLP-/GIP dual agonists is achieved by combining an increase in energy expenditure with a decrease in food intake [130], and its potential in the treatment of obesity has been validated in clinical trials

If the FDA approves GLP-1 weight loss patches in the future, patients using the patches may experience similar side effects as subcutaneous GLP-1 injections, including GI-related adverse effects

That triple mechanism is what produced the headline-grabbing results from the Phase 2 NEJM trial, where the 12 mg dose group achieved an average 24.2% body weight reduction over 48 weeks

The incomplete capture of AEs hampers the comprehensiveness of the database, rendering it challenging to obtain a holistic understanding of a drugs safety profile