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Reactions resolve without intervention within hours to days

The severity of injury or inflammation can affect how long it remains active at the target site

Trial durations were relatively short, typically 12 weeks maximum

Reduce to once-daily evening application only

Research applications Research applications In vitro assays of ECM regulation (collagen, elastin) and MMP/TIMP balance Cell migration, proliferation, and cellular migration and tissue-matrix development models (fibroblasts, keratinocytes) Anti-inflammatory and antioxidant signaling studies (NF-B, Nrf2 pathways) Copper-dependent enzymatic and metalloregulator investigations Mechanistic combination studies with growth factors, cytokines, or small molecules For laboratory research use only

PGI2 probably increases Th2 cell function by IP (PGI2 receptor) to reduce the production of IL-1, IL-6, and monocyte chemoattractant protein (MCP)-1 (162)